Description

tert-Butyl 4-(5-formyl-2-thienyl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a reactive aldehyde group on a thiophene ring, protected by a Boc (tert-butoxycarbonyl) group on the piperazine nitrogen. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for drug discovery programs, particularly in creating libraries of bioactive compounds.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies, enabling the introduction of diverse substituents via the formyl group.
• API (Active Pharmaceutical Ingredient) Development: Serves as a critical building block in the multi-step synthesis of potential new active ingredients, especially those containing piperazine and heterocyclic motifs.
• CNS Drug Candidates: Employed in the research and development of therapeutics targeting neurological receptors and pathways where the piperazine-thiophene core is pharmacologically relevant.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions for clinical trials.

Basic Information

Product Name	tert-Butyl 4-(5-Formyl-2-Thienyl)Piperazine-1-Carboxylate
CAS No.	623588-30-7
Molecular Formula	C14H20N2O3S
Molecular Weight	296.38 g/mol
Synonyms	1-Boc-4-(5-formyl-2-thienyl)piperazine; 4-(5-Formyl-2-thienyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(5-formylthiophen-2-yl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(5-formyl-2-thienyl)piperazine; Boc-4-(5-formyl-2-thienyl)piperazine; 623588-30-7; 5-Formyl-2-thienyl piperazine Boc derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-formyl-2-thienyl)piperazine-1-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our partners with the documentation necessary for regulatory filings and quality audits.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.