Description

3-Fluoroazetidine Hydrochloride is a high-value, fluorinated azetidine building block essential for modern pharmaceutical and agrochemical research. This compound is prized for its ability to introduce the metabolically stable, three-membered azetidine ring with a fluorine substituent, which can significantly alter the physicochemical and biological properties of target molecules. It is a critical intermediate for medicinal chemists and process R&D teams in the pharmaceutical, biotechnology, and crop protection industries seeking to develop novel active ingredients with improved potency and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitor and GPCR-targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to modulate lipophilicity, metabolic stability, and bioavailability.
• Agrochemical Research: Building block for the synthesis of advanced herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology: Probe and tool compound synthesis for studying biological pathways and protein-ligand interactions.
• Process Chemistry: Scalable intermediate for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Fluorine Chemistry: A versatile reagent for introducing fluorine into complex molecular architectures.

Basic Information

Product Name	3-Fluoroazetidine Hydrochloride
CAS No.	617718-46-4
Molecular Formula	C3H7ClFN
Molecular Weight	111.55 g/mol
Synonyms	3-Fluoroazetidine HCl; 3-Fluoro-azetidine hydrochloride; Azetidine, 3-fluoro-, hydrochloride; 3-Fluoroazetidine Hydrochloride Salt; 3-Fluorazetidin Hydrochlorid; 3-Fluoroazetidinium Chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoroazetidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, guaranteeing compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.