Description

1-(4-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethanone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both bromo and fluoro substituents on the phenyl ring and a trifluoroacetyl group, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic electronic materials due to its electron-withdrawing properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethanone
CAS No.	617706-18-0
Molecular Formula	C8H3BrF4O
Molecular Weight	271.01 g/mol
Synonyms	4'-Bromo-2'-fluoro-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-bromo-2-fluorophenyl)ethanone; 1-(4-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one; 4-Bromo-2-fluoro-α,α,α-trifluoroacetophenone; p-Bromo-o-fluoro-α,α,α-trifluoroacetophenone; (4-Bromo-2-fluorophenyl)(trifluoro)methanone; 2-Fluoro-4-bromo-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP commercial scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.