Description

1-(5-Chloro-2-Fluorophenyl)-2,2,2-Trifluoroethanone is a high-value fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl groups on a fluorinated phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a crucial building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its fluorine content which can influence solubility and electronic properties.
• Chemical Development: Employed in process chemistry for scaling up the production of fluorinated target molecules, benefiting from its well-defined reactivity.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	1-(5-Chloro-2-Fluorophenyl)-2,2,2-Trifluoroethanone
CAS No.	617706-16-8
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	5-Chloro-2-fluorobenzoyl trifluoromethane; 5-Chloro-2-fluorophenyl trifluoromethyl ketone; 2-Fluoro-5-chlorobenzotrifluoride; 1-(5-Chloro-2-fluorophenyl)-2,2,2-trifluoroethan-1-one; 2-Fluoro-5-chloro-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-5-chloro-2-fluoroacetophenone; Trifluoro(5-chloro-2-fluorophenyl)methanone
EINECS	Contact for details

Quality Control

Our production of 1-(5-Chloro-2-Fluorophenyl)-2,2,2-Trifluoroethanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.