Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline Hydrochloride is a high-purity, protected aniline boronic ester derivative, essential as a key synthetic intermediate in modern organic and medicinal chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is critically needed by research and development laboratories, pharmaceutical manufacturers, and agrochemical companies for the synthesis of advanced molecules, including active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in constructing complex aromatic and heteroaromatic systems via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific biaryl structures.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biological target identification and assay development.
• Academic & Contract Research: A staple reagent in university and CRO laboratories for methodological development and the synthesis of complex organic molecules.
• Ligand & Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline Hydrochloride
CAS No.	616227-14-6
Molecular Formula	C12H19BClNO2
Molecular Weight	255.55 g/mol
Synonyms	4-Aminophenylboronic acid pinacol ester hydrochloride; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine hydrochloride; 4-(Pinacolatoboryl)aniline hydrochloride; 4-Boronoaniline pinacol ester hydrochloride; 4-Aminobenzene-1-boronic acid pinacol ester HCl; 4-(Pinacolboron)aniline HCl; 4-(Pinacolboryl)aniline hydrochloride; 4-(Pinanediol boronic ester)aniline hydrochloride (common alternative).
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.