Description

(S)-(-)-N,n-Dimethyl-3-Hydroxy-(2-Thienyl)-Propanamine CAS NO 606086-94-6 is a high-purity chiral amine derivative featuring a thiophene moiety, serving as a critical intermediate in advanced organic synthesis. Its enantiomeric purity and unique heterocyclic structure make it indispensable for constructing complex molecules with specific stereochemical and pharmacological profiles. This compound is primarily sought by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialized ligands for catalysis.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the specific stereochemistry influences biological activity.
• Catalyst & Ligand Development: Serves as a precursor for chiral ligands in asymmetric catalysis, enabling enantioselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical fidelity.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.
• Material Science: Potential monomer or additive for creating functional polymers with tailored electronic or optical properties derived from the thiophene unit.

Basic Information

Product Name	(S)-(-)-N,n-Dimethyl-3-Hydroxy-(2-Thienyl)-Propanamine
CAS No.	606086-94-6
Molecular Formula	C9H15NOS
Molecular Weight	185.29 g/mol
Synonyms	(S)-(-)-Duloxetine Intermediate; (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol; (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propylamine; (S)-(-)-N,N-Dimethyl-3-(2-thienyl)-3-hydroxypropylamine; Thiophene propanolamine derivative; (S)- enantiomer of LY248686; Duloxetine related compound S
EINECS	Contact for details

Quality Control

Our (S)-(-)-N,n-Dimethyl-3-Hydroxy-(2-Thienyl)-Propanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.