Description

Boronic Acid, B-[2,3-Difluoro-4-(Trimethylsilyl)Phenyl]- is a high-purity, organoboron building block featuring a unique difluoro-substituted phenyl ring protected by a trimethylsilyl group. This compound is critical for enabling complex cross-coupling reactions, particularly in the synthesis of advanced pharmaceutical intermediates and functional materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality reagents for Suzuki-Miyaura coupling and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate complex aromatic structures.
• Material Science & OLED Development: Serves as a building block for creating organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and sensors that leverage boronic acid chemistry for detecting sugars or other analytes.
• Polymer Chemistry: Can be incorporated as a functional monomer or cross-linking agent in specialty polymers.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	Boronic Acid, B-[2,3-Difluoro-4-(Trimethylsilyl)Phenyl]-
CAS No.	603990-25-6
Molecular Formula	C15H23BF2O2Si
Molecular Weight	312.24 g/mol
Synonyms	(2,3-Difluoro-4-(trimethylsilyl)phenyl)boronic acid; B-(2,3-Difluoro-4-(trimethylsilyl)phenyl)boronic acid; 2,3-Difluoro-4-(trimethylsilyl)benzeneboronic acid; [2,3-Difluoro-4-(trimethylsilyl)phenyl]boronic acid; 4-Trimethylsilyl-2,3-difluorophenylboronic acid; 2,3-Difluoro-4-trimethylsilylbenzeneboronic acid; Boronic acid, B-[2,3-difluoro-4-(trimethylsilyl)phenyl]-
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-[2,3-Difluoro-4-(Trimethylsilyl)Phenyl]- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. All products undergo rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation, as boronic acids can be sensitive to protic conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.