Description

2-(Difluoromethyl)Lysine is a specialized, fluorinated derivative of the essential amino acid L-lysine, characterized by the introduction of a difluoromethyl group. This structural modification is of significant interest for its role in the research and development of novel enzyme inhibitors and mechanism-based inactivators, particularly targeting lysine-specific biological pathways. It serves as a critical building block and research chemical for pharmaceutical chemists and biochemists working in drug discovery, proteomics, and chemical biology. The compound is essential for synthesizing modified peptides and studying protein function and interactions.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel therapeutic agents, especially enzyme inhibitors.
• Chemical Biology Probe: Used to study enzyme mechanisms, particularly for lysine-modifying enzymes like demethylases and deacetylases, via mechanism-based inhibition.
• Proteomics Research: Employed in the synthesis of activity-based probes (ABPs) for labeling and identifying specific enzyme families in complex biological systems.
• Peptide Synthesis: Serves as a modified amino acid building block for introducing fluorinated motifs into peptides, altering their stability, binding affinity, and metabolic properties.
• Academic & Institutional Research: Fundamental research tool in universities and institutes for investigating fluorine biochemistry and post-translational modifications.

Basic Information

Product Name	2-(Difluoromethyl)Lysine
CAS No.	69955-47-1
Molecular Formula	C7H14F2N2O2
Molecular Weight	196.20 g/mol
Synonyms	2-(Difluoromethyl)-L-lysine; (2S)-2-Amino-6-[(difluoromethyl)amino]hexanoic acid; L-Lysine, 2-(difluoromethyl)-; DFML; 2-DFML; Nε-Difluoromethyl-L-lysine; 6-[(Difluoromethyl)amino]-L-norleucine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Lysine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.