Description

3β,16β-Bis(Trimethylsiloxy)Androst-5-En-17-One o-(Trimethylsilyl)Oxime is a high-purity, steroidal intermediate featuring multiple trimethylsilyl (TMS) protecting groups, which enhance its stability and solubility for advanced synthetic processes. This compound is critical for research and development in the pharmaceutical sector, particularly in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and reference standards. It is primarily utilized by fine chemical manufacturers, R&D laboratories, and pharmaceutical companies specializing in endocrinology and metabolic disease therapeutics.

Application

• Key Intermediate in Steroid API Synthesis: Serves as a protected precursor in the multi-step synthesis of novel steroid hormones and their analogs.
• Pharmaceutical Research & Development: Used in the discovery and process development of new therapeutic agents targeting hormone receptors.
• Reference Standard Production: Employed as a high-purity building block for the preparation of certified reference materials (CRMs) and analytical standards.
• Process Chemistry & Scale-Up: Valued for its defined stereochemistry and protecting groups, enabling efficient and reproducible scale-up from lab to pilot plant.
• Academic & Institutional Research: Utilized in university and institutional labs for studying steroid biochemistry and developing new synthetic methodologies.

Basic Information

Product Name	3β,16β-Bis(Trimethylsiloxy)Androst-5-En-17-One o-(Trimethylsilyl)Oxime
CAS No.	69833-81-4
Molecular Formula	C29H55NO3Si3
Molecular Weight	558.02 g/mol
Synonyms	Androst-5-ene-17-one, 3,16-bis[(trimethylsilyl)oxy]-, O-[(trimethylsilyl)imino]-; 3β,16β-Bis(trimethylsiloxy)androst-5-en-17-one O-(trimethylsilyl)oxime; 69833-81-4; 3,16-Bis-O-TMS-androst-5-en-17-one O-TMS-oxime; Steroid TMS Derivative; 17-Oximinoandrostane TMS Ether
EINECS	Contact for details

Quality Control

Our production of 3β,16β-Bis(Trimethylsiloxy)Androst-5-En-17-One o-(Trimethylsilyl)Oxime adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.