Description

Trifluoromethanesulfonic Acid tert-Butyldimethylsilyl Ester is a highly versatile and reactive silylating agent, specifically a silyl triflate, valued for its exceptional ability to introduce the tert-butyldimethylsilyl (TBDMS) protecting group under mild conditions. This compound is critical for synthetic chemists as it facilitates the selective protection of alcohols, phenols, and other nucleophiles in complex multi-step syntheses, enabling the construction of sensitive pharmaceutical intermediates and advanced organic molecules. It is an essential reagent for R&D and production in pharmaceutical development, agrochemical synthesis, and advanced material science.

Application

• Protecting Group Chemistry: Selective protection of primary and secondary alcohols as TBDMS ethers in the synthesis of complex natural products and active pharmaceutical ingredients (APIs).
• Nucleoside and Carbohydrate Chemistry: Key reagent for the protection of hydroxyl groups in the synthesis of modified nucleosides, nucleotides, and complex sugars.
• Polymer and Material Science: Used as a silylating agent to modify surface properties or to create functional monomers and precursors for silicone-based polymers.
• Agrochemical Synthesis: Intermediate in the multi-step synthesis of advanced herbicides, fungicides, and plant growth regulators requiring selective protection/deprotection strategies.
• Peptide Synthesis: Employed for the temporary protection of serine, threonine, or tyrosine side chains during solid-phase or solution-phase peptide synthesis.
• Analytical Derivatization: Used to derivative polar compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis to improve volatility and detection.

Basic Information

Item	Details
Product Name	Trifluoromethanesulfonic Acid tert-Butyldimethylsilyl Ester
CAS No.	69739-34-0
Molecular Formula	C9H19F3O3SSi
Molecular Weight	292.39 g/mol
Synonyms	tert-Butyldimethylsilyl Trifluoromethanesulfonate; TBDMS Triflate; tert-Butyldimethylsilyl Triflate; TBDMSOTf; (tert-Butyldimethylsilyl) Trifluoromethanesulfonate; 1,1,1-Trifluoro-N-(tert-butyldimethylsilyl)methanesulfonamide? (incorrect but common misnomer); TBS-Triflate; Silicon, tert-butyldimethyl-, trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our Trifluoromethanesulfonic Acid tert-Butyldimethylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and the absence of critical impurities that could impact sensitive synthetic applications. Certificates of Analysis (COA) detailing comprehensive specifications are available upon request, supporting compliance with internal quality standards for research and cGMP manufacturing where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.