Description

1-O,2-O,3-O,5-o-Tetrakis(Trimethylsilyl)-D-Galactofuranose Phosphoric Acid Bis(Trimethylsilyl) Ester is a highly specialized, fully protected carbohydrate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive, silyl-protected galactofuranose scaffold with a phosphotriester group, enabling precise and efficient glycosylation and phosphorylation reactions. This compound is essential for researchers and process chemists in pharmaceutical development, particularly for synthesizing nucleoside analogs, complex glycoconjugates, and prodrugs where the galactofuranose moiety is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Glycoconjugate Synthesis: Used in the preparation of complex oligosaccharides, glycopeptides, and glycolipids for biological studies and drug discovery.
• Prodrug Development: Serves as a protected precursor for creating masked or targeted prodrug forms of therapeutic agents.
• Chemical Biology Tool: Employed in the study of carbohydrate-processing enzymes and the construction of molecular probes.
• Oligonucleotide Chemistry: Potential use in the synthesis of modified oligonucleotides where sugar-phosphate backbone alterations are desired.
• Academic & Industrial R&D: Fundamental reagent for methodological development in synthetic organic and medicinal chemistry.

Basic Information

Item	Details
Product Name	1-O,2-O,3-O,5-o-Tetrakis(Trimethylsilyl)-D-Galactofuranose Phosphoric Acid Bis(Trimethylsilyl) Ester
CAS No.	69688-48-8
Molecular Formula	C24H61O9PSi6
Molecular Weight	677.29 g/mol
Synonyms	D-Galactofuranose, 1,2,3,5-tetrakis-O-(trimethylsilyl)-, cyclic phosphite (3:1); 1,2,3,5-Tetra-O-trimethylsilyl-D-galactofuranose cyclic methylphosphonite; Fully protected D-galactofuranose phosphotriester; TMS-protected galactofuranose phosphite; Galactofuranosyl phosphoramidite precursor; CAS 69688-48-8
EINECS	Contact for details

Quality Control

Every batch of 1-O,2-O,3-O,5-o-Tetrakis(Trimethylsilyl)-D-Galactofuranose Phosphoric Acid Bis(Trimethylsilyl) Ester is produced and analyzed under strict quality protocols to ensure consistency and purity for sensitive synthetic applications. Our quality assurance includes comprehensive analytical characterization using NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and suitability for use as a high-value research chemical.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, this compound must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.