Description

12β-(Trimethylsiloxy)Androst-4-Ene-3,17-Dione is a high-value, steroidal intermediate featuring a strategically protected hydroxyl group at the 12-beta position. This compound is critical for the synthesis of complex steroid-based pharmaceuticals and fine chemicals, offering a key building block for advanced research and development. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers specializing in steroid chemistry and hormone-related therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel steroidal drugs, including potential anti-inflammatory, anti-cancer, and hormonal agents.
• Research & Development: Serves as a crucial precursor in academic and industrial research for exploring new steroid derivatives and their biological activities.
• Process Chemistry: Used in the development and scale-up of synthetic routes for complex steroid molecules in pilot plants and commercial manufacturing.
• Fine Chemical Synthesis: Employed in the production of high-purity, specialty steroids for diagnostic applications and reference standards.

Basic Information

Product Name	12β-(Trimethylsiloxy)Androst-4-Ene-3,17-Dione
CAS No.	69688-28-4
Molecular Formula	C22H34O3Si
Molecular Weight	374.60 g/mol
Synonyms	12β-(Trimethylsilyloxy)androst-4-ene-3,17-dione; 12β-TMS-Androstenedione; Androst-4-ene-3,17-dione, 12β-(trimethylsiloxy)-; 12β-Hydroxyandrost-4-ene-3,17-dione trimethylsilyl ether; 12β-TMS-O-Androstenedione; 12β-Trimethylsiloxyandrost-4-ene-3,17-dione
EINECS	Contact for details

Quality Control

Our 12β-(Trimethylsiloxy)Androst-4-Ene-3,17-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements of pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.