Description

2,5-Difluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in its ability to introduce both the difluorophenyl moiety and a reactive cyano group, which can be further transformed into various functional groups like carboxylic acids, amides, or amines. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Serves as a starting material for synthesizing electron-deficient units in organic semiconductors and OLED materials.
• Cross-Coupling Reactions: The aromatic ring can undergo various palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) for constructing complex molecular architectures.
• Fine Chemical Research: Valuable reagent in academic and industrial labs for exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	2,5-Difluorophenylacetonitrile
CAS No.	69584-87-8
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	(2,5-Difluorophenyl)acetonitrile; 2,5-Difluorobenzeneacetonitrile; α-Cyano-2,5-difluorotoluene; 2,5-Difluorobenzyl cyanide; 2,5-Difluoro-ω-cyanotoluene; (2,5-Difluorophenyl)ethanenitrile; 69584-87-8; 2,5-DFPAN
EINECS	Contact for details

Quality Control

Our 2,5-Difluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.