Description

(R)-Homopipecolicacid CAS NO 69222-96-4 is a high-purity, non-proteinogenic amino acid derivative belonging to the pipecolic acid family, characterized by its specific (R)-enantiomeric configuration. This chiral building block is of significant value in pharmaceutical research and development, particularly for the synthesis of complex molecules with defined stereochemistry. It serves as a critical intermediate for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate constrained, chiral amino acid motifs into their target compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in protease inhibitor and neurological drug candidates.
• Peptidomimetics & Constrained Peptide Design: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and biological activity.
• Ligand Synthesis for Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Building block for novel herbicides, fungicides, and plant growth regulators with specific chiral activity.
• Biochemical Research: Tool compound for studying enzyme mechanisms and as a standard in analytical method development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or non-GMP conditions.

Basic Information

Product Name	(R)-Homopipecolicacid
CAS No.	69222-96-4
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(R)-2-Azepanecarboxylic Acid; (R)-Hexahydro-2H-azepine-2-carboxylic Acid; (R)-2-Carboxyazepane; (R)-Aminoepiocaproic Acid; (R)-Homopipecolate; (R)-HPA; (2R)-Hexahydro-1H-azepine-2-carboxylic Acid; (R)-2-Piperidineacetic Acid, homologue
EINECS	Contact for details

Quality Control

Our (R)-Homopipecolicacid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing assay, enantiomeric excess (ee), and impurity profile is supplied with every shipment. We support development from research to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect stability and handling properties. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.