Description

5-(Bromomethyl)-3-Phenyl-4,5-Dihydroisoxazole is a versatile brominated isoxazoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its reactive bromomethyl group makes it a valuable electrophile for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where precise functionalization is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in the development of central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the isoxazoline scaffold for biological activity.
• Chemical Biology Probe Development: Serves as a precursor for creating activity-based probes to study enzyme function and protein interactions.
• Material Science Research: Employed in the synthesis of specialized polymers and functional materials with tailored properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form carbon-carbon bonds.
• Nucleophilic Substitution Scaffold: The bromomethyl group is readily displaced by various nucleophiles (amines, thiols, alkoxides) for library synthesis.

Basic Information

Product Name	5-(Bromomethyl)-3-Phenyl-4,5-Dihydroisoxazole
CAS No.	68843-61-8
Molecular Formula	C10H10BrNO
Molecular Weight	240.10 g/mol
Synonyms	3-Phenyl-5-(bromomethyl)-4,5-dihydroisoxazole; 5-(Bromomethyl)-3-phenyl-2-isoxazoline; 3-Phenyl-5-(bromomethyl)-2-isoxazoline; 4,5-Dihydro-3-phenyl-5-(bromomethyl)isoxazole; Isoxazoline, 5-(bromomethyl)-3-phenyl-4,5-dihydro-; Bromomethyl phenyl dihydroisoxazole
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)-3-Phenyl-4,5-Dihydroisoxazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.