Description

2-Bromo-6-[(1S,2R,5R)-1,2-Dimethylbicyclo[3.1.0]Hexan-2-Yl]-3-Methylphenol is a high-purity, stereochemically defined phenolic compound with a complex bicyclic framework, serving as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis. Its unique sterically hindered structure makes it valuable for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated chiral motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the specific stereochemistry influences biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating sterically demanding ligands used in asymmetric catalysis.
• Material Science Research: Potential monomer or additive for developing polymers with specific thermal or optical properties.
• Academic & R&D: A valuable tool for synthetic organic chemists exploring new reaction methodologies and complex natural product analogs.
• Flavor & Fragrance Industry: Intermediate for synthesizing complex odorants and flavoring agents with unique olfactory profiles.

Basic Information

Product Name	2-Bromo-6-[(1S,2R,5R)-1,2-Dimethylbicyclo[3.1.0]Hexan-2-Yl]-3-Methylphenol
CAS No.	68773-09-1
Molecular Formula	C15H19BrO
Molecular Weight	295.22 g/mol
Synonyms	2-Bromo-6-[(1S,2R,5R)-1,2-dimethylbicyclo[3.1.0]hexan-2-yl]-3-methylphenol; (1S,2R,5R)-2-(2-Bromo-6-hydroxy-3-methylphenyl)-1,2-dimethylbicyclo[3.1.0]hexane; 2-Bromo-6-(1,2-dimethylbicyclo[3.1.0]hexan-2-yl)-3-methylphenol (stereoisomer); Bicyclo[3.1.0]hexane phenol derivative; Brominated dimethylbicyclohexyl methylphenol
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-[(1S,2R,5R)-1,2-Dimethylbicyclo[3.1.0]Hexan-2-Yl]-3-Methylphenol is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing specifications such as chiral purity, chemical purity (HPLC), and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, and open flames. The container must be kept tightly closed to prevent oxidation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1S,2R,5R isomer)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.