Description

(2R,3S)-2,3-Dihydroxy-2-Isopropylbutanoic Acid [(1R,7As)-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex pharmaceutical molecules, particularly those requiring specific three-dimensional architecture for biological activity. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, especially in antiviral, antibacterial, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides where specific stereochemistry is crucial for efficacy and environmental safety.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical fidelity.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting research in synthetic methodology and medicinal chemistry.
• Process Chemistry Development: Used by process chemists to scale up and optimize synthetic routes for the commercial production of chiral molecules.

Basic Information

Product Name	(2R,3S)-2,3-Dihydroxy-2-Isopropylbutanoic Acid [(1R,7As)-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester
CAS No.	68473-85-8
Molecular Formula	C15H27NO4
Molecular Weight	285.38 g/mol
Synonyms	(2R,3S)-2,3-Dihydroxy-3-methylpentanoic Acid (1R,7aS)-Octahydro-1H-pyrrolizin-1-ylmethyl Ester; (1R,7aS)-Octahydro-1H-pyrrolizin-1-ylmethyl (2R,3S)-2,3-dihydroxy-3-methylpentanoate; L-Pyrrolizidine-1-carboxylic Acid, (2R,3S)-2,3-Dihydroxy-3-methyl-1-oxopentyl Ester; A Chiral Pyrrolizidine Alkaloid Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (2R,3S)-2,3-Dihydroxy-2-Isopropylbutanoic Acid [(1R,7As)-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your research or cGMP guidelines for non-GMP intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.