Description

n-α-T-Butyloxycarbonyl-L-Alaninyl-Diazomethane, (3S)-3-Boc-Amino-1-Diazo-2-Butanone is a specialized, high-value Boc-protected diazoketone building block used in advanced organic synthesis. This compound is critical for introducing the alanine moiety via carbene insertion or Wolff rearrangement reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide & Peptidomimetic Synthesis: A key intermediate for the site-specific incorporation of alanine and other amino acid derivatives via homologation reactions.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly in medicinal chemistry for lead optimization.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and other tools for studying enzyme function and protein interactions.
• Heterocycle Formation: Serves as a precursor in cyclization reactions to create complex nitrogen-containing heterocyclic scaffolds common in many drugs.
• Material Science Research: Potential use in the synthesis of specialized polymers and functional materials with tailored properties.

Basic Information

Item	Details
Product Name	n-α-T-Butyloxycarbonyl-L-Alaninyl-Diazomethane, (3S)-3-Boc-Amino-1-Diazo-2-Butanone
CAS No.	67919-80-6
Molecular Formula	C10H17N3O4
Molecular Weight	243.26 g/mol
Synonyms	(3S)-3-[(tert-Butoxycarbonyl)amino]-1-diazo-2-butanone; N-Boc-L-alaninyl diazomethane; Boc-L-Ala-CHN2; 1-Diazo-3-[(2-methyl-2-propanyloxy)carbonyl]amino-2-butanone; tert-Butyl ((1S)-1-(diazoacetyl)propyl)carbamate; (S)-3-(Boc-amino)-1-diazo-2-butanone; N-α-t-Butyloxycarbonyl-L-alaninyl-diazomethane; Boc-Ala-CHN2
EINECS	Contact for details

Quality Control

Our n-α-T-Butyloxycarbonyl-L-Alaninyl-Diazomethane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation due to oxidation and moisture. Allow the container to reach room temperature in a desiccator before opening to minimize condensation and exposure to air. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.