Description

(3S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Pentanone is a high-value, chiral diazoketone building block used in advanced organic synthesis. This compound is critical for the controlled introduction of nitrogen-containing functional groups and for constructing complex molecular architectures via carbene insertion reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), natural products, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those requiring stereospecific nitrogen incorporation.
• Peptidomimetic Research: Used in the construction of peptide backbones and non-natural amino acid derivatives for drug discovery.
• Carbene Chemistry Precursor: Serves as a safe and stable precursor for metal carbene generation, enabling C-H insertion, cyclopropanation, and other catalytic transformations.
• Agrochemical Synthesis: Employed in the development of novel herbicides and insecticides with specific stereochemical requirements.
• Academic & Process R&D: A valuable tool for methodology development in organic chemistry laboratories and for scaling up synthetic routes.
• Ligand and Catalyst Development: Used to create novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	(3S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Pentanone
CAS No.	67865-71-8
Molecular Formula	C11H19N3O3
Molecular Weight	241.29 g/mol
Synonyms	1-Diazo-4-methyl-2-pentanone, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (3S)-; (S)-3-((tert-Butoxycarbonyl)amino)-1-diazo-4-methylpentan-2-one; Boc-L-Diazonorvaline Ketone; (S)-3-(Boc-amino)-1-diazo-4-methyl-2-pentanone; (3S)-3-[(tert-Butoxycarbonyl)amino]-1-diazo-4-methylpentan-2-one; N-Boc-L-2-amino-4-methylvaleric acid diazomethyl ketone; L-Diazonorvaline, N-Boc- derivative
EINECS	Contact for details

Quality Control

Our (3S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Pentanone is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. We adhere to cGMP principles where applicable to support our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or COA. This material is strictly light-sensitive and easily oxidized; it should be stored under an inert atmosphere (e.g., nitrogen or argon) in its original sealed container to maintain stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.