Description

Sodium Tri-sec-Butylborohydride CAS NO 67276-04-4 is a highly selective and powerful reducing agent, specifically a sterically hindered borohydride salt. This compound matters for its superior chemoselectivity and thermal stability compared to other borohydride reagents, enabling precise transformations in sensitive synthetic sequences. It is primarily needed by process chemists and researchers in the pharmaceutical, agrochemical, and fine chemical industries for the selective reduction of carbonyls, reductive amination, and other critical synthetic steps.

Application

• Selective Carbonyl Reduction: Preferred for the stereoselective reduction of ketones and aldehydes in complex molecules where standard reagents lack selectivity.
• Pharmaceutical Intermediate Synthesis: A key reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for chiral alcohol formation.
• Asymmetric Synthesis: Employed in conjunction with chiral auxiliaries or catalysts to produce enantiomerically enriched alcohols.
• Reductive Amination: Used in the efficient one-pot conversion of carbonyl compounds to amines, a fundamental reaction in medicinal chemistry.
• Fine Chemical Manufacturing: Applied in the production of specialty chemicals, flavors, and fragrances requiring high-purity intermediates.
• Polymer Chemistry: Utilized as a modifying agent or initiator in the synthesis of specialized polymeric materials.
• Academic & Industrial R&D: A valuable tool in research laboratories for developing new synthetic methodologies and exploring novel chemical spaces.

Basic Information

Product Name	Sodium Tri-sec-Butylborohydride
CAS No.	67276-04-4
Molecular Formula	C12H28BNa
Molecular Weight	206.16 g/mol
Synonyms	Sodium Tri-secondary-Butylborohydride; Sodium Tris(sec-butyl)borohydride; Sodium Tri-sec-butylborohydride; Na-Selectride® (Trade Name); Selectride® Reducing Agent; Sodium Hydridotris(sec-butyl)borate(1-); Tris(sec-butyl)borohydride Sodium Salt; Borate(1-), hydridotris(2-butyl)-, sodium
EINECS	Contact for details

Quality Control

Our Sodium Tri-sec-Butylborohydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent reactivity, and lot-to-lot reproducibility. Certificates of Analysis (COA) detailing assay, impurity profile, and solution stability are provided and available upon request. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or suspension
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Purity (NMR)	≥ 90.0%
Solvent (if applicable)	Specified (e.g., Toluene, THF)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.