Description

5-Ethyl-5-[1-(Ethylthio)Ethyl]-2-Sodiooxy-4,6(1H,5H)-Pyrimidinedione is a specialized sodium salt derivative of a barbiturate analog, valued for its role as a key synthetic intermediate in advanced pharmaceutical manufacturing. This compound matters for its precise chemical functionality, enabling the development of active pharmaceutical ingredients (APIs) with specific therapeutic profiles. It is primarily needed by research institutions and fine chemical producers engaged in the synthesis of central nervous system (CNS) agents, sedatives, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of barbiturate-derived active pharmaceutical ingredients (APIs).
• Neurological Drug Research: Used in R&D for developing novel sedative, hypnotic, and anticonvulsant compounds targeting the central nervous system.
• Fine Chemical Synthesis: Serves as a specialized reagent for introducing the thiethyl-substituted pyrimidinedione moiety into complex molecular architectures.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Chemical Biology Studies: Utilized in probing biological mechanisms related to GABA receptor modulation and related pathways.

Basic Information

Product Name	5-Ethyl-5-[1-(Ethylthio)Ethyl]-2-Sodiooxy-4,6(1H,5H)-Pyrimidinedione
CAS No.	66968-27-2
Molecular Formula	C10H15N2NaO3S
Molecular Weight	266.29 g/mol
Synonyms	5-Ethyl-5-(1-ethylthioethyl)barbituric acid sodium salt; Sodium 5-ethyl-5-(1-ethylthioethyl)-2,4,6-pyrimidinetrione; 5-Ethyl-5-(1-ethylthioethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium derivative; Thiobarbiturate sodium salt; 2-Thio-5,5-disubstituted barbiturate sodium salt; NSC 113928; Sodium 5-ethyl-5-(α-ethylthioethyl)barbiturate
EINECS	Contact for details

Quality Control

Our 5-Ethyl-5-[1-(Ethylthio)Ethyl]-2-Sodiooxy-4,6(1H,5H)-Pyrimidinedione is manufactured under a strict quality management system. All batches undergo rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.