Description

(+)-2-Acetoxypropanal CAS NO 66875-69-2 is a chiral, enantiomerically pure aldehyde derivative, serving as a versatile and high-value building block in asymmetric synthesis. Its core value lies in providing a stereodefined acetate-protected aldehyde functionality, enabling the controlled introduction of chiral centers into complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemistry for developing active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in antiviral, anti-inflammatory, and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides, herbicides, and plant growth regulators where specific stereochemistry is critical for bioactivity.
• Fine Chemical Manufacturing: Employed in the asymmetric synthesis of flavors, fragrances, and other specialty chemicals requiring high optical purity.
• Academic & R&D: A valuable reagent in organic chemistry research for developing new asymmetric methodologies and total synthesis of natural products.
• Peptide Mimetics & Modifications: Useful for introducing chiral aldehydes or protected glycolaldehyde units into peptide backbones or side chains.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	(+)-2-Acetoxypropanal
CAS No.	66875-69-2
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	(R)-2-Acetoxypropanal; (R)-(+)-2-Acetoxypropanal; D-2-Acetoxypropanal; (R)-Acetoxyacetaldehyde; (R)-1-Acetoxy-1-oxopropane; (2R)-2-Acetoxypropanal; (R)-2-Acetoxy-1-oxopropane; Glycolaldehyde acetate (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (+)-2-Acetoxypropanal is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, assay by titration or GC, and identification by IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/Titration)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.