Description

(2R,3S)-3-Hydroxy-2-Methyl-Butanoic Acid CAS NO 66729-02-0 is a high-purity, stereochemically defined hydroxy acid, also known as (2R,3S)-3-Hydroxy-2-methylbutyric acid. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceuticals, fine chemicals, and advanced materials. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries where precise stereochemistry is required for biological activity and process efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, antibiotic, and cardiovascular drug development.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereoisomers exhibit enhanced efficacy and lower environmental impact.
• Fine Chemical Production: Serves as a building block for flavors, fragrances, and other high-value specialty chemicals requiring defined stereochemistry.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies, metabolic pathway analysis, and as a precursor in biocatalysis.
• Polymer Chemistry: Can be utilized as a monomer or co-monomer for creating functionalized polymers with specific chiral centers.
• Asymmetric Synthesis Catalyst Ligand: Acts as a precursor for chiral ligands used in metal-catalyzed asymmetric reactions.

Basic Information

Product Name	(2R,3S)-3-Hydroxy-2-Methyl-Butanoic Acid
CAS No.	66729-02-0
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	(2R,3S)-3-Hydroxy-2-methylbutyric acid; (2R,3S)-2-Methyl-3-hydroxybutanoic acid; D-three-3-Hydroxy-2-methylbutyric acid; (2R,3S)-2-Methyl-3-hydroxybutyric acid; 3-Hydroxy-2-methylbutanoic acid (specifying stereochemistry); 66729-02-0; Hydroxymethylbutyric acid isomer
EINECS	Contact for details

Quality Control

Our (2R,3S)-3-Hydroxy-2-Methyl-Butanoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R,3S)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.