Description

2-Methyl-4-Oxo-4-(3'-Trifluoromethylphenyl)Butyric Acid is a high-value trifluoromethylated organic intermediate with significant synthetic utility. This compound is prized for its role in constructing complex molecules, particularly in the pharmaceutical sector, where the trifluoromethyl group is a key pharmacophore enhancing metabolic stability and lipophilicity. It is essential for research chemists and process development scientists in fine chemical, agrochemical, and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a key starting material for synthesizing fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Custom & Contract Synthesis: Employed in research laboratories and CDMOs for the custom synthesis of complex, fluorinated target molecules for client projects.
• Chemical Research & Development: A versatile reagent for exploring new reaction methodologies, particularly in palladium-catalyzed cross-coupling and carbonyl chemistry.

Basic Information

Product Name	2-Methyl-4-Oxo-4-(3'-Trifluoromethylphenyl)Butyric Acid
CAS No.	66549-17-5
Molecular Formula	C12H11F3O3
Molecular Weight	260.21 g/mol
Synonyms	4-(3-(Trifluoromethyl)phenyl)-2-methyl-4-oxobutanoic acid; 2-Methyl-4-oxo-4-[3-(trifluoromethyl)phenyl]butanoic acid; 4-Oxo-4-(3-trifluoromethylphenyl)-2-methylbutyric acid; α-Methyl-β-(3-trifluoromethylbenzoyl)propionic acid; 3'-Trifluoromethyl-2-methyl-4-oxo-4-phenylbutyric acid; Butyric acid, 2-methyl-4-oxo-4-[3-(trifluoromethyl)phenyl]-; CAS 66549-17-5
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-Oxo-4-(3'-Trifluoromethylphenyl)Butyric Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.