Description

tert-Butyl-Methoxy-Dimethylsilane is a specialized organosilicon compound, CAS NO 66548-21-8, valued for its role as a versatile silylating agent and protecting group in complex organic synthesis. Its unique steric bulk and reactivity profile make it a critical reagent for modifying molecular structures with high selectivity. This chemical is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced material science sectors, where precise control over functional groups is paramount.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protecting group for alcohols and other sensitive functional groups during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Employed in the manufacture of advanced pesticides and herbicides where specific silicon-containing intermediates are required.
• Polymer & Material Science: Acts as a precursor or modifying agent in the synthesis of specialty silicones, siloxane-based polymers, and surface coatings.
• Organic Synthesis Reagent: Serves as a key silylating agent in laboratory-scale and industrial organic reactions to introduce the tert-butyldimethylsilyl (TBDMS) group.
• Flavor & Fragrance Industry: Utilized in the synthesis of certain aroma chemicals and flavoring compounds that require silicon-based protecting strategies.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	tert-Butyl-Methoxy-Dimethylsilane
CAS No.	66548-21-8
Molecular Formula	C7H18OSi
Molecular Weight	146.30 g/mol
Synonyms	tert-Butyldimethylmethoxysilane; Methoxy(tert-butyl)dimethylsilane; (tert-Butyl)dimethylmethoxysilane; TBDMS Methoxide; tert-Butyldimethylsilyl Methyl Ether; Dimethyl-tert-butylsilyl Methyl Ether; Silane, methoxy(1,1-dimethylethyl)dimethyl-; 1-(tert-Butyl)-1,1-dimethyl-1-methoxysilane
EINECS	Contact for details

Quality Control

Our tert-Butyl-Methoxy-Dimethylsilane is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain purity and prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	0.78 - 0.82 g/mL
Refractive Index (n20/D)	1.405 - 1.415

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.