Description

(3S)-3,4,4A,5,6,7,8,8Aβ-Octahydro-8α-Hydroxymethyl-4α-[(E)-5-Hydroxy-3-Methyl-3-Pentenyl]-3β,4Aα,8-Trimethylnaphthalen-2(1H)-One is a high-purity, complex sesquiterpenoid derivative with a defined stereochemistry, valued for its role as a key synthetic intermediate. This compound is essential for researchers and manufacturers requiring precise molecular scaffolds for advanced chemical synthesis. It is primarily utilized in the pharmaceutical and fine chemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in steroid and terpenoid-based therapeutic research.
• Fine Chemical Synthesis: Used in the production of complex, high-value specialty chemicals and advanced materials requiring specific stereochemical configurations.
• Fragrance & Flavor Precursor: Acts as a starting material for the synthesis of sophisticated aroma compounds and flavorants in the perfumery and food industries.
• Agrochemical Research: Employed in the development of new plant growth regulators or bioactive agents with terpenoid backbones.
• Academic & R&D: A valuable reference standard and reagent for organic chemistry research, catalysis studies, and methodological development in total synthesis.

Basic Information

Product Name	(3S)-3,4,4A,5,6,7,8,8Aβ-Octahydro-8α-Hydroxymethyl-4α-[(E)-5-Hydroxy-3-Methyl-3-Pentenyl]-3β,4Aα,8-Trimethylnaphthalen-2(1H)-One
CAS No.	66471-78-1
Molecular Formula	C21H34O3
Molecular Weight	334.50 g/mol
Synonyms	8α-Hydroxymethyl-4α-[(E)-5-hydroxy-3-methyl-3-penten-1-yl]-3β,4aα,8-trimethyl-decahydronaphthalen-2(1H)-one; (3S)-3,4,4a,5,6,7,8,8a-Octahydro-8α-(hydroxymethyl)-4α-[(E)-5-hydroxy-3-methyl-3-penten-1-yl]-3β,4aα,8-trimethylnaphthalen-2(1H)-one; A key intermediate for Ambrox synthesis; Sesquiterpenoid alcohol ketone; Tetrahydroambrox precursor.
EINECS	Contact for details

Quality Control

Our (3S)-3,4,4A,5,6,7,8,8Aβ-Octahydro-8α-Hydroxymethyl-4α-[(E)-5-Hydroxy-3-Methyl-3-Pentenyl]-3β,4Aα,8-Trimethylnaphthalen-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for stereochemical integrity, and spectroscopic identification (NMR, IR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.