Description

8-(Chlorosulphonyl)-3,4-Dihydro-2H-Benzo-1,5-Dioxepin-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzo-fused dioxepin ring system and reactive chlorosulfonyl moiety. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• API Synthesis: Employed as a building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring the benzo-1,5-dioxepin scaffold.
• Chemical Derivatization: The reactive chlorosulfonyl group allows for further functionalization, making it valuable for creating libraries of compounds for high-throughput screening.
• Fine Chemical Production: Used in the manufacture of specialized fine chemicals and advanced materials where its specific heterocyclic structure is required.

Basic Information

Product Name	8-(Chlorosulphonyl)-3,4-Dihydro-2H-Benzo-1,5-Dioxepin-6-Carboxylic Acid
CAS No.	66410-81-9
Molecular Formula	C11H9ClO6S
Molecular Weight	304.70 g/mol
Synonyms	8-(Chlorosulfonyl)-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid; 2H-1,5-Benzodioxepin-6-carboxylic acid, 3,4-dihydro-8-(chlorosulfonyl)-; 8-Chlorosulfonyl-3,4-dihydro-2H-benzo[b][1,5]dioxepin-6-carboxylic acid; Benzo-1,5-dioxepin-6-carboxylic acid, 8-chlorosulfonyl-3,4-dihydro-; 66410-81-9; 8-(Chlorosulfonyl)-3,4-dihydro-2H-1,5-benzodioxepine-6-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 8-(Chlorosulphonyl)-3,4-Dihydro-2H-Benzo-1,5-Dioxepin-6-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.