Description

n-(tert-Butyldimethylsilyl)Dimethyl- is a specialized organosilicon compound, specifically a silylating agent, widely recognized for its role in protecting sensitive functional groups during complex synthetic sequences. Its primary value lies in providing robust, selective protection for hydroxyl groups, which is critical for achieving high yields and purity in multi-step organic synthesis. This reagent is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable intermediates for the production of active pharmaceutical ingredients (APIs), fine chemicals, and novel polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key protecting group reagent in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide & Nucleotide Chemistry: Used to protect hydroxyl groups on sugar moieties and amino acid side chains during oligonucleotide and peptide synthesis.
• Agrochemical Production: Intermediate in the manufacture of advanced pesticides and herbicides where selective protection is required.
• Material Science Research: Employed in the synthesis of siloxane-based polymers, dendrimers, and other specialty materials.
• Academic & Industrial R&D: A staple reagent in organic chemistry laboratories for method development and exploratory synthesis.
• Fine Chemical Manufacturing: Facilitates the production of high-value, complex organic compounds where traditional protection strategies fail.

Basic Information

Product Name	n-(tert-Butyldimethylsilyl)Dimethyl-
CAS No.	66365-05-7
Molecular Formula	C8H21NSi
Molecular Weight	159.35 g/mol
Synonyms	N-(tert-Butyldimethylsilyl)dimethylamine; tert-Butyldimethylsilyl dimethylamine; TBS-DMA; Dimethyl(tert-butyldimethylsilyl)amine; N-Dimethyl-N-(tert-butyldimethylsilyl)amine; (Dimethylamino)(tert-butyldimethyl)silane; N-(tert-Butyldimethylsilyl)-N-methylmethanamine
EINECS	Contact for details

Quality Control

Our production of n-(tert-Butyldimethylsilyl)Dimethyl- adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. While produced under cGMP-compatible conditions for pharmaceutical relevance, each lot is supported by a comprehensive Certificate of Analysis (COA). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (nitrogen or argon) in its original sealed packaging to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~0.78 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.