Description

(2E)-3-Methyl-4-[[(2S)-3α,4α-Dihydroxy-5β-[[(2S,3S)-3-[(1S,2S)-1-Methyl-2-Hydroxypropyl]Oxiranyl]Methyl]Tetrahydro-2H-Pyran]-2β-Yl]-2-Butenoic Acid Ethyl Ester is a complex, high-purity chiral intermediate with significant synthetic utility. This compound matters for its role as a key building block in the synthesis of advanced pharmaceutical agents, particularly those with intricate stereochemical requirements. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, where precise molecular architecture is critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for complex molecules targeting specific biological pathways.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for method development and the construction of novel chemical entities with defined stereochemistry.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, where consistent quality and purity are paramount.
• Asymmetric Catalysis Studies: Acts as a substrate or a ligand precursor in studies aimed at developing new catalytic asymmetric transformations.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	(2E)-3-Methyl-4-[[(2S)-3α,4α-Dihydroxy-5β-[[(2S,3S)-3-[(1S,2S)-1-Methyl-2-Hydroxypropyl]Oxiranyl]Methyl]Tetrahydro-2H-Pyran]-2β-Yl]-2-Butenoic Acid Ethyl Ester
CAS No.	66262-53-1
Molecular Formula	C20H34O7
Molecular Weight	386.48 g/mol
Synonyms	Ethyl (2E)-3-Methyl-4-[(2S,3S,4S,5S,6R)-3,4-dihydroxy-6-[[(2S,3S)-3-[(2S,3S)-2-hydroxy-3-methylbutyl]oxiran-2-yl]methyl]-5-methyloxan-2-yl]but-2-enoate; (2E,2'β,3α,4α,5β)-Ethyl 3-Methyl-4-(3,4-dihydroxy-5-[[3-[(1-methyl-2-hydroxypropyl)oxiranyl]]methyl]tetrahydro-2H-pyran-2-yl)-2-butenoate; A key intermediate for Simvastatin synthesis; Simvastatin hydroxy acid ethyl ester derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (2E)-3-Methyl-4-[[(2S)-3α,4α-Dihydroxy-5β-[[(2S,3S)-3-[(1S,2S)-1-Methyl-2-Hydroxypropyl]Oxiranyl]Methyl]Tetrahydro-2H-Pyran]-2β-Yl]-2-Butenoic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. Recommended long-term storage at 2-8°C. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.