Description

2-(2,3-Dihydro-1H-Indol-5-Yl)-1,1,1,3,3,3-Hexafluoro-Propan-2-Ol is a high-value fluorinated indole derivative, a key building block in advanced organic synthesis. Its core value lies in the unique combination of the indole heterocycle and the hexafluoroisopropanol moiety, which imparts significant lipophilicity and metabolic stability to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, due to the indole scaffold's prevalence in bioactive molecules.
• Agrochemical Research: Used in developing new generation pesticides and herbicides, where the fluorine atoms enhance compound stability, bioavailability, and membrane permeability.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and coatings with enhanced chemical resistance and unique surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry and catalysis research to construct sophisticated chiral ligands or metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the effects of polyfluorinated groups on molecular conformation and reactivity.
• Diagnostic Agent Synthesis: Potential use in the development of contrast agents or radiotracers for medical imaging techniques like PET or MRI.

Basic Information

Item	Details
Product Name	2-(2,3-Dihydro-1H-Indol-5-Yl)-1,1,1,3,3,3-Hexafluoro-Propan-2-Ol
CAS No.	65797-54-8
Molecular Formula	C11H9F6NO
Molecular Weight	285.19 g/mol
Synonyms	5-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)indoline; 2-(2,3-Dihydro-1H-indol-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol; 5-(Hexafluoro-2-hydroxyisopropyl)indoline; 1,1,1,3,3,3-Hexafluoro-2-(2,3-dihydro-1H-indol-5-yl)propan-2-ol; 2-(Indolin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol; HFIP-Indoline derivative; CAS 65797-54-8
EINECS	Contact for details

Quality Control

Our 2-(2,3-Dihydro-1H-Indol-5-Yl)-1,1,1,3,3,3-Hexafluoro-Propan-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.