Description

(1R,4E,5S)-4-Ethylidene-1,3,4,5,6,8-Hexahydro-2-Methyl-13-Methylene-1β,5β-Methanoazonino[4,3-B]Indol-7(2H)-One is a complex, high-purity alkaloid derivative with a unique polycyclic structure. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the synthesis of novel bioactive molecules. It serves as a critical advanced intermediate for researchers and manufacturers in the life sciences sector requiring sophisticated chemical building blocks.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and synthesis of potential new active pharmaceutical ingredients (APIs) with complex stereochemistry.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of novel therapeutic agents targeting neurological or oncological pathways.
• Organic Synthesis Reference Standard: Serves as a high-purity standard for analytical method development and validation in QC laboratories.
• Biochemical Research: Potential use as a probe or ligand in biochemical assays and for studying enzyme interactions due to its intricate molecular architecture.
• Process Chemistry Development: Employed in scaling up synthetic routes for complex natural product analogs and specialty fine chemicals.

Basic Information

Product Name	(1R,4E,5S)-4-Ethylidene-1,3,4,5,6,8-Hexahydro-2-Methyl-13-Methylene-1β,5β-Methanoazonino[4,3-B]Indol-7(2H)-One
CAS No.	65617-99-4
Molecular Formula	C19H22N2O
Molecular Weight	294.39 g/mol
Synonyms	4-Ethylidene-1,3,4,5,6,8-hexahydro-2-methyl-13-methylene-1β,5β-methanoazonino[4,3-b]indol-7(2H)-one; 1β,5β-Methanoazonino[4,3-b]indol-7(2H)-one, 4-ethylidene-1,3,4,5,6,8-hexahydro-2-methyl-13-methylene-, (1R,4E,5S)-; (1R,4E,5S)-4-Ethylidene-1,3,4,5,6,8-hexahydro-2-methyl-13-methylene-1,5-methanoazonino[4,3-b]indol-7(2H)-one; Alkaloid C-19 Derivative; Azoninoindolone Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical specifications such as assay, chiral purity, and related substances. We support compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.