Description

3-[(Benzyloxycarbonyl)Amino]Propionaldehyde is a versatile and high-value protected amino aldehyde building block used in advanced organic synthesis. Its primary value lies in its dual functionality, serving as a key precursor for the controlled introduction of nitrogen-containing moieties and aldehyde groups in complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of peptide mimetics, heterocyclic compounds, and other bioactive intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors and other nitrogen-rich drug candidates.
• Peptidomimetic Synthesis: Used to incorporate aldehyde handles into peptide chains for the creation of stabilized peptide analogs and constrained structures.
• Heterocyclic Chemistry: Serves as a starting material for the construction of pyrrolidines, piperidines, and other nitrogen-containing heterocycles via reductive amination or cyclization reactions.
• Linker Molecule in Bioconjugation: The aldehyde group allows for selective conjugation with amines, enabling its use in creating antibody-drug conjugates (ADCs) or other bioconjugates.
• Chiral Auxiliary and Resin Synthesis: Employed in the preparation of chiral auxiliaries and functionalized solid-phase synthesis resins for combinatorial chemistry.
• Agrochemical Research: Acts as a precursor in the development of novel herbicides and fungicides that require specific amino-aldehyde functionalities.

Basic Information

Product Name	3-[(Benzyloxycarbonyl)Amino]Propionaldehyde
CAS No.	65564-05-8
Molecular Formula	C11H13NO3
Molecular Weight	207.23 g/mol
Synonyms	N-Cbz-3-Aminopropionaldehyde; (3-Oxo-propyl)-carbamic acid benzyl ester; Z-3-Aminopropionaldehyde; Cbz-β-alaninal; N-[(Benzyloxy)carbonyl]-3-aminopropanal; 3-[(Benzyloxycarbonyl)amino]propanal; N-Carbobenzoxy-3-aminopropionaldehyde; 3-(N-Cbz-amino)propionaldehyde
EINECS	Contact for details

Quality Control

Our 3-[(Benzyloxycarbonyl)Amino]Propionaldehyde is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool, and well-ventilated area. Due to its sensitivity, allow the container to reach room temperature before opening to minimize moisture condensation and oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.