Description

Aflatoxin B1-Formamidopyrimidine is a chemically modified derivative of the potent mycotoxin Aflatoxin B1, specifically its formamidopyrimidine (FAPY) adduct. This compound is of critical importance as a reference standard and biomarker for studying DNA damage and mutagenesis caused by aflatoxin exposure. It is primarily required by analytical laboratories, research institutions, and diagnostic manufacturers engaged in toxicology, food safety, and cancer research to ensure accurate detection and quantification of aflatoxin-induced genetic lesions.

Application

• Biomarker Reference Standard: Used as a primary standard for the calibration and validation of analytical methods (e.g., HPLC-MS/MS, ELISA) designed to detect aflatoxin-DNA adducts in biological samples.
• Toxicological Research: Essential for in vitro and in vivo studies investigating the mechanisms of aflatoxin B1 genotoxicity, mutagenicity, and carcinogenicity.
• Food and Feed Safety Analysis: Supports method development for monitoring aflatoxin exposure and DNA damage in populations consuming contaminated commodities.
• Diagnostic Kit Development: Serves as a critical antigen or hapten in the production of antibodies for immunoassay-based diagnostic kits targeting aflatoxin adducts.
• Environmental Monitoring: Applied in research assessing the long-term health impacts of aflatoxin exposure in occupational and environmental settings.
• Pharmacokinetic Studies: Utilized to trace the metabolic activation of Aflatoxin B1 and its subsequent binding to DNA, aiding in risk assessment models.

Basic Information

Product Name	Aflatoxin B1-Formamidopyrimidine
CAS No.	65386-83-6
Molecular Formula	C20H17N5O6
Molecular Weight	423.38 g/mol
Synonyms	AFB1-FAPY; Aflatoxin B1 Formamidopyrimidine Adduct; AFB1-N7-Guanine FAPY Adduct; 8,9-Dihydro-8-(N5-formyl-5,6,7,9-tetrahydro-9-oxoimidazo[1,2-a]purin-7-yl)-9-hydroxy-aflatoxin B1; AFB1–FAPY adduct; Aflatoxin B1–DNA Adduct (FAPY); Imidazole ring-opened AFB1–N7-Gua adduct
EINECS	Contact for details

Quality Control

Our Aflatoxin B1-Formamidopyrimidine is produced and handled under strict quality protocols suitable for research and analytical use. Each batch undergoes rigorous identity confirmation and purity analysis. Certificates of Analysis (COA) detailing lot-specific results from techniques such as NMR, HPLC, and MS are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. Store in a dedicated, secure area for toxic compounds.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC-MS)	Conforms to reference
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.