Description

(R)-(+)-Trityl Glycidyl Ether is a high-value, chiral glycidyl ether derivative, prized for its role as a versatile chiral building block in asymmetric synthesis. Its significance lies in the trityl-protecting group, which offers steric bulk and stability, enabling selective reactions crucial for constructing complex, optically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for developing enantiomerically pure active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in β-blockers and other cardiovascular or neurological drugs.
• Asymmetric Catalyst Ligand Precursor: Used in the development of chiral ligands for transition metal catalysts, enhancing stereoselectivity in hydrogenation and cross-coupling reactions.
• Chiral Polymer Synthesis: Serves as a monomer for creating optically active epoxy resins and polymers with specific chiral functionalities for advanced material science.
• Agrochemical Synthesis: Employed in the production of chiral herbicides, fungicides, and pesticides where the specific enantiomer exhibits the desired biological activity.
• Fine Chemical and Specialty Chemical Production: Utilized in custom synthesis and contract manufacturing for high-value, low-volume specialty chemicals requiring precise stereochemistry.
• Academic and R&D Laboratories: A critical reagent for methodological development in organic chemistry and for exploring new synthetic pathways in academic research.

Basic Information

Product Name	(R)-(+)-Trityl Glycidyl Ether
CAS No.	65291-30-7
Molecular Formula	C22H20O2
Molecular Weight	316.40 g/mol
Synonyms	(R)-(+)-Triphenylmethyl Glycidyl Ether; (R)-Trityl Glycidyl Ether; (R)-TGME; (R)-(+)-TGME; (R)-Glycidyl Trityl Ether; (2R)-2-[(Triphenylmethoxy)methyl]oxirane; (R)-(-)-1,2-Epoxy-3-(triphenylmethoxy)propane; (R)-O-Trityl Glycidol
EINECS	Contact for details

Quality Control

Our (R)-(+)-Trityl Glycidyl Ether is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and purity assays. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	85 - 89 °C
Specific Rotation [α]D20	+15.0° to +18.0° (c=1 in CHCl3)
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.