Description

(S)-4-Methyl-2-oxetanone (CAS 65058-82-4) is a high-value, enantiomerically pure lactone derivative that serves as a critical chiral building block in advanced organic synthesis. Its defined stereochemistry and reactive lactone ring make it indispensable for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-amino acids, protease inhibitors, and other biologically active molecules requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides and fungicides, where the (S)-configuration can be crucial for bioactivity.
• Polymer Science: Acts as a monomer or co-monomer for the synthesis of specialized, biodegradable polyesters with tailored properties.
• Flavor & Fragrance Industry: Serves as a precursor for the synthesis of chiral lactone-based flavor compounds and aroma chemicals.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in the development and study of new asymmetric catalytic processes.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(S)-4-Methyl-2-oxetanone
CAS No.	65058-82-4
Molecular Formula	C4H6O2
Molecular Weight	86.09 g/mol
Synonyms	(S)-β-Butyrolactone; (S)-3-Methyl-β-propiolactone; (S)-4-Methyloxetan-2-one; (S)-3-Methyl-2-oxetanone; (S)-3-Methyl-β-lactone; (S)-(-)-β-Hydroxybutyric acid lactone; (S)-HBL; (S)-BHB lactone
EINECS	Contact for details

Quality Control

Every batch of (S)-4-Methyl-2-oxetanone is produced under strict quality management protocols. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing identity, purity (typically >98% by HPLC), enantiomeric excess (typically >99% ee), and impurity profile is supplied with each shipment. Our quality system is designed to support cGMP manufacturing for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.