Description

6-Cyano-trans-3-Bromo-3,4-Dihydro-2,2-Dimethyl-2H-Benzo-[B]-Pyran-4-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its specific chiral and functional group architecture. This compound matters for its role as a critical building block in the synthesis of complex organic molecules, offering precise stereochemical control for downstream applications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) or anti-infective therapies.
• Agrochemical Synthesis: Used in the construction of novel, biologically active molecules for crop protection and pest management.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.
• Fine Chemical Production: Employed in the multistep synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic & Institutional Research: A valuable compound for methodological studies in organic synthesis, medicinal chemistry, and total synthesis projects.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	6-Cyano-trans-3-Bromo-3,4-Dihydro-2,2-Dimethyl-2H-Benzo-[B]-Pyran-4-Ol
CAS No.	65018-89-5
Molecular Formula	C₁₃H₁₂BrNO₂
Molecular Weight	294.15 g/mol
Synonyms	trans-3-Bromo-6-cyano-3,4-dihydro-2,2-dimethyl-4-hydroxy-2H-1-benzopyran; 3-Bromo-6-cyano-3,4-dihydro-2,2-dimethyl-4-hydroxy-2H-chromene; 2H-1-Benzopyran-4-ol, 3-bromo-6-cyano-3,4-dihydro-2,2-dimethyl-, trans-; 65018-89-5; Benzo[b]pyran-4-ol, 6-cyano-3-bromo-3,4-dihydro-2,2-dimethyl-, trans-; Chroman-4-ol derivative
EINECS	Contact for details

Quality Control

Our 6-Cyano-trans-3-Bromo-3,4-Dihydro-2,2-Dimethyl-2H-Benzo-[B]-Pyran-4-Ol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent any potential moisture uptake. Handle and store in accordance with all applicable local regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.