Description

(1β,3β,4α,6β)-1,6-Dimethylbicyclo[4.1.0]Heptane-3,4-Dicarboxylic Acid Dimethyl Ester is a high-purity, specialized bicyclic dicarboxylic acid ester with a defined stereochemistry, serving as a critical chiral building block and synthetic intermediate. Its value lies in its rigid, functionalized molecular framework, which is essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for applications in medicinal chemistry, asymmetric synthesis, and the development of advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical control.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce complex, polycyclic structures into target molecules.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals, flavors, and fragrances.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: Used in chemical research to study reaction mechanisms, ring strain, and the properties of bicyclic systems.

Basic Information

Product Name	(1β,3β,4α,6β)-1,6-Dimethylbicyclo[4.1.0]Heptane-3,4-Dicarboxylic Acid Dimethyl Ester
CAS No.	64918-86-1
Molecular Formula	C13H20O4
Molecular Weight	240.30 g/mol
Synonyms	Dimethyl (1R,3R,4S,6R)-1,6-Dimethylbicyclo[4.1.0]heptane-3,4-dicarboxylate; (1R,3R,4S,6R)-1,6-Dimethylbicyclo[4.1.0]heptane-3,4-dicarboxylic Acid Dimethyl Ester; 1,6-Dimethylbicyclo[4.1.0]heptane-3,4-dicarboxylic Acid Dimethyl Ester; Bicyclo[4.1.0]heptane-3,4-dicarboxylic Acid, 1,6-Dimethyl-, Dimethyl Ester, (1R,3R,4S,6R)-; Chiral Bicyclic Diester; NSC 338243
EINECS	Contact for details

Quality Control

Our production of (1β,3β,4α,6β)-1,6-Dimethylbicyclo[4.1.0]Heptane-3,4-Dicarboxylic Acid Dimethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and residual solvent analysis to ensure it meets exacting R&D and cGMP-starting material standards. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.