Description

1-(2,4-Difluorophenyl)-4,4,4-Trifluorobutane-1,3-Dione is a high-purity fluorinated diketone building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethyl and difluorophenyl groups, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for fluorinated polymers, ligands, and complex organic frameworks with specialized electronic or surface properties.
• Chemical Research: Employed in academic and industrial laboratories for methodology development, including studies on fluorination effects and chelate chemistry.
• Ligand and Catalyst Development: Useful for synthesizing β-diketonate ligands used in coordination chemistry and catalysis.

Basic Information

Product Name	1-(2,4-Difluorophenyl)-4,4,4-Trifluorobutane-1,3-Dione
CAS No.	64287-18-9
Molecular Formula	C10H5F5O2
Molecular Weight	252.14 g/mol
Synonyms	1-(2,4-Difluorophenyl)-1,3-butanedione, 4,4,4-trifluoro-; 4,4,4-Trifluoro-1-(2,4-difluorophenyl)butane-1,3-dione; 2,4-Difluorophenyl trifluoroacetylacetone; 1,3-Butanedione, 1-(2,4-difluorophenyl)-4,4,4-trifluoro-; 2',4'-Difluoro-4,4,4-trifluoroacetylacetone; DFBT; 2,4-DFBA
EINECS	Contact for details

Quality Control

Our 1-(2,4-Difluorophenyl)-4,4,4-Trifluorobutane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. Certificates of Analysis (COA) with lot-specific data are provided to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.