Description

(R)-5,6,7,8-Tetrahydro-3-Hydroxy-7-Isopropenyl-1-Naphthalenecarbaldehyde is a high-purity, chiral intermediate of significant importance in advanced organic synthesis. This compound matters because it serves as a critical building block for the development of complex, biologically active molecules, particularly in the pharmaceutical sector. Industries that need it include pharmaceutical R&D, fine chemical manufacturing, and academic research institutions focused on asymmetric synthesis and natural product chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Catalysis Research: Used as a starting material or ligand precursor in the development of novel catalytic systems for enantioselective reactions.
• Natural Product Synthesis: Serves as a core structural unit in the laboratory synthesis of terpenoid and steroid-based natural products.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals and advanced materials.
• Reference Standard: Utilized as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Academic & Industrial R&D: A valuable tool for chemists exploring new reaction methodologies and constructing complex molecular architectures.

Basic Information

Product Name	(R)-5,6,7,8-Tetrahydro-3-Hydroxy-7-Isopropenyl-1-Naphthalenecarbaldehyde
CAS No.	64185-18-8
Molecular Formula	C₁₄H₁₈O₂
Molecular Weight	218.29 g/mol
Synonyms	(R)-3-Hydroxy-7-isopropenyl-5,6,7,8-tetrahydronaphthalene-1-carbaldehyde; (R)-7-Isopropenyl-3-hydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene-1-carboxaldehyde; (R)-Perillaldehyde derivative; (R)-Tetrahydroperillaldehyde alcohol; (R)-THPA; (R)-Isopropenyltetrahydronaphthalenecarbaldehyde; (3R)-3-Hydroxy-7-(prop-1-en-2-yl)-1,2,3,5,6,7-hexahydronaphthalene-1-carbaldehyde
EINECS	Contact for details

Quality Control

Our (R)-5,6,7,8-Tetrahydro-3-Hydroxy-7-Isopropenyl-1-Naphthalenecarbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.