Description

Rac Atomoxetine CAS NO 63940-51-2 is the racemic form of a selective norepinephrine reuptake inhibitor (NRI). This compound is of significant value as a key intermediate and reference standard in pharmaceutical research and development. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and R&D institutions for the synthesis, quality control, and metabolic studies of the active pharmaceutical ingredient atomoxetine hydrochloride.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of atomoxetine hydrochloride, the active ingredient in medications for Attention Deficit Hyperactivity Disorder (ADHD).
• Analytical Reference Standard: Used as a certified reference material (CRM) in High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and mass spectrometry for method development, validation, and quality control testing.
• Metabolite Studies: Employed in preclinical and clinical research to investigate the metabolic pathways, pharmacokinetics, and pharmacodynamics of atomoxetine and its enantiomers.
• Process Chemistry R&D: Utilized in the development and optimization of synthetic routes, including chiral separation techniques, to produce the therapeutically active (R)-(-)-enantiomer.
• Impurity Profiling: Acts as a known impurity standard to monitor and control the enantiomeric purity of the final drug substance during manufacturing.

Basic Information

Product Name	Rac Atomoxetine
CAS No.	63940-51-2
Molecular Formula	C17H21NO
Molecular Weight	255.36 g/mol
Synonyms	Atomoxetine Racemate; (±)-Atomoxetine; (R,S)-Atomoxetine; N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine; LY-139603; Tomoxetine Racemate; (RS)-Tomoxetine; (Rac)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine
EINECS	Contact for details

Quality Control

Our Rac Atomoxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC assay), and specified impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≤ 1.0% (by chiral HPLC)
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.