Description

Malonic Acid Bis(Fluoromethyl) Ester is a specialized fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the reactivity of the fluoromethyl ester groups, which serve as versatile handles for introducing fluorine-containing motifs into target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides with enhanced properties through fluorine incorporation.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating specialty polymers with unique surface properties or stability.
• Fluorine Chemistry Research: Essential reagent in academic and industrial R&D for studying new fluorination methodologies and creating fluorinated molecular libraries.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for catalysis and molecular recognition applications.
• Diagnostic Agent Synthesis: Potential intermediate in the production of fluorinated contrast agents or radiotracers for medical imaging (e.g., PET).

Basic Information

Product Name	Malonic Acid Bis(Fluoromethyl) Ester
CAS No.	63917-08-8
Molecular Formula	C5H6F2O4
Molecular Weight	168.10 g/mol
Synonyms	Bis(fluoromethyl) malonate; Fluoromethyl malonate; Propanedioic acid, bis(fluoromethyl) ester; Malonic acid, bis(fluoromethyl) ester; Di(fluoromethyl) malonate; 2-Fluoromethyl malonate; Fluoromethyl propanedioate
EINECS	Contact for details

Quality Control

Our Malonic Acid Bis(Fluoromethyl) Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to verify identity and quantify impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP and ISO 9001 standards for research and development materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and sources of fluoride ions. The container should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.