Description

Lithium Hydrotriisobutylborate(1-) is a highly reactive organoboron reagent, specifically a lithium trialkylborohydride, known for its exceptional reducing power and selectivity. This compound is a critical tool for synthetic chemists, enabling precise and efficient transformations in complex molecule construction. It is primarily utilized in the pharmaceutical, agrochemical, and advanced materials research sectors for demanding reduction and hydroboration reactions where superior control is required.

Application

• Selective Carbonyl Reduction: A powerful and sterically hindered reducing agent for the chemoselective reduction of aldehydes, ketones, and acid chlorides in the presence of other sensitive functional groups.
• Asymmetric Synthesis: Employed in the synthesis of chiral intermediates for active pharmaceutical ingredients (APIs) and fine chemicals due to its predictable stereochemical outcomes.
• Hydroboration Agent: Used in the hydroboration of alkenes and alkynes to generate organoborane intermediates for subsequent cross-coupling reactions (e.g., Suzuki-Miyaura coupling).
• Pharmaceutical Intermediate Manufacturing: A key reagent in multi-step syntheses for constructing complex molecular scaffolds found in drug candidates.
• Polymer Chemistry: Facilitates the synthesis and modification of specialty polymers and advanced materials by enabling controlled functional group transformations.
• Academic & Industrial R&D: A staple in research laboratories for developing novel synthetic methodologies and exploring new chemical spaces.

Basic Information

Product Name	Lithium Hydrotriisobutylborate(1-)
CAS No.	63717-73-7
Molecular Formula	C12H28BLi
Molecular Weight	190.10 g/mol
Synonyms	Lithium Triisobutylborohydride; L-Selectride® (common trade name); Lithium Hydrotriisobutylborate; Lithium tri-sec-butylborohydride; LiB(i-Bu)3H; Lithium tris(2-methylpropyl)borohydride; Tris(2-methylpropyl)borohydride lithium salt
EINECS	Contact for details

Quality Control

Our Lithium Hydrotriisobutylborate(1-) is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay/purity, solution concentration (typically in THF), and impurity profiles. Our quality system is designed to meet the rigorous demands of GMP-aligned production for pharmaceutical intermediates and other high-value applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; all handling and packaging must be conducted under anhydrous, oxygen-free conditions to maintain purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to slightly yellow solution
Identification (IR)	Conforms
Assay (Titration)	≥ 1.0 M in THF (or as specified)
Purity (NMR)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.