Description

4-Chloro-3-(Trifluoromethyl)-Dl-Phenylalanine, 97% is a high-purity, non-natural amino acid derivative featuring both chloro and trifluoromethyl substituents on the phenyl ring. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce structural complexity and modulate the physicochemical properties of target molecules. It is primarily utilized by research institutions and pharmaceutical development teams engaged in medicinal chemistry, agrochemical research, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and receptor antagonist programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore the effects of halogen and fluorine substitution on potency, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and pesticides, where the trifluoromethyl group is a common bioisostere.
• Peptidomimetics & Peptide Engineering: Incorporated into peptide backbones to create analogs with enhanced stability against enzymatic degradation and altered binding profiles.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for labeling and modifying proteins or for creating activity-based probes to study enzyme function.

Basic Information

Item	Details
Product Name	4-Chloro-3-(Trifluoromethyl)-Dl-Phenylalanine, 97%
CAS No.	63687-03-6
Molecular Formula	C10H9ClF3NO2
Molecular Weight	267.63 g/mol
Synonyms	DL-4-Chloro-3-(trifluoromethyl)phenylalanine; (±)-2-Amino-3-[4-chloro-3-(trifluoromethyl)phenyl]propanoic acid; 4-Chloro-α-amino-3-(trifluoromethyl)benzenepropanoic acid (racemic); 4-Chloro-3-trifluoromethyl-DL-phenylalanine; 2-Amino-3-(4-chloro-3-(trifluoromethyl)phenyl)propanoic acid; 63687-03-6; DL-p-Cl-CF3-Phe-OH
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethyl)-Dl-Phenylalanine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and compliance with customer specifications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if frequent access is required to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.