Description

2-(2'-Pyridyldithio)Benzyldiazoacetate is a specialized bifunctional chemical linker featuring both a diazoacetate group and a cleavable pyridyl disulfide moiety. This compound is critical for creating stable yet reversible covalent bonds in advanced bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and polymer industries for site-specific protein modification, drug delivery system development, and the synthesis of smart biomaterials.

Application

• Bioconjugation Reagent: For site-specific crosslinking and labeling of proteins, antibodies, and peptides via its reactive diazoacetate group.
• Drug Delivery Systems: As a cleavable linker in antibody-drug conjugates (ADCs) and other targeted therapeutics, where the disulfide bond is reduced in the intracellular environment.
• Surface Functionalization: To immobilize biomolecules onto gold nanoparticles, biosensor chips, and other surfaces through the pyridyl disulfide-thiol exchange reaction.
• Polymer Chemistry: As a monomer or crosslinker for synthesizing stimuli-responsive hydrogels and polymers with disulfide linkages.
• Diagnostic Assay Development: For constructing enzyme-linked immunosorbent assay (ELISA) kits and other diagnostic platforms requiring stable protein conjugates.
• Affinity Chromatography: In the preparation of activated resins for the purification of thiol-containing biomolecules.

Basic Information

Product Name	2-(2'-Pyridyldithio)Benzyldiazoacetate
CAS No.	63681-84-5
Molecular Formula	C15H11N3O2S2
Molecular Weight	329.39 g/mol
Synonyms	2-(2-Pyridinyldithio)benzyl diazoacetate; Benzyl 2-diazo-2-[2-(2-pyridinyldithio)ethoxy]acetate; 2-(Pyridin-2-yldisulfanyl)benzyl diazoacetate; PDBA; PDS-Diazoacetate; Diazoacetate-Pyridyl Disulfide Crosslinker; 2-(2'-Pyridyldithio)benzyl 2-diazoacetate
EINECS	Contact for details

Quality Control

Our 2-(2'-Pyridyldithio)Benzyldiazoacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated place. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.