Description

2-Amino-4,4,4-Trifluoro-Butyric Acid Ethyl Ester is a high-value fluorinated amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique trifluoromethyl group imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated analogs of bioactive molecules, peptides, and potential drug candidates.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Peptide Chemistry: Incorporation into custom peptides to study structure-activity relationships (SAR) and improve peptide stability against enzymatic degradation.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals with unique optical and electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Asymmetric Synthesis: Acts as a versatile starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral centers.

Basic Information

Product Name	2-Amino-4,4,4-Trifluoro-Butyric Acid Ethyl Ester
CAS No.	63664-50-6
Molecular Formula	C6H10F3NO2
Molecular Weight	185.15 g/mol
Synonyms	Ethyl 2-Amino-4,4,4-trifluorobutanoate; 4,4,4-Trifluoro-DL-norvaline Ethyl Ester; DL-2-Amino-4,4,4-trifluorobutyric Acid Ethyl Ester; Ethyl 4,4,4-Trifluoronorvalinate; 2-Azaniumyl-4,4,4-trifluorobutanoate Ethyl Ester; Ethyl α-Amino-γ,γ,γ-trifluorobutyrate; Norvaline, 4,4,4-trifluoro-, ethyl ester; TFAB-OEt
EINECS	Contact for details

Quality Control

Our 2-Amino-4,4,4-Trifluoro-Butyric Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.