Description

trans-Methyl 3-Hydroxycyclobutanecarboxylate is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its unique cyclobutane ring fused with hydroxyl and ester functionalities makes it a versatile precursor for constructing complex molecular architectures. This compound is particularly sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in programs targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced, high-performance pesticides and herbicides, where the cyclobutane scaffold can contribute to unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with tailored thermal and mechanical properties.
• Fragrance and Flavor Chemistry: Acts as an intermediate for synthesizing specific odorants and flavor compounds with complex, strained-ring structures.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	trans-Methyl 3-Hydroxycyclobutanecarboxylate
CAS No.	63485-51-8
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	trans-Methyl 3-hydroxycyclobutanecarboxylate; Methyl (1r,3r)-3-Hydroxycyclobutanecarboxylate; (1r,3r)-3-Hydroxycyclobutanecarboxylic Acid Methyl Ester; trans-3-Hydroxycyclobutanecarboxylic Acid Methyl Ester; Methyl trans-3-Hydroxycyclobutanecarboxylate; (1R,3R)-Methyl 3-hydroxycyclobutanecarboxylate; 3-Hydroxycyclobutanecarboxylic acid methyl ester, trans-; Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester, (1R,3R)-
EINECS	Contact for details

Quality Control

Our trans-Methyl 3-Hydroxycyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is moisture-sensitive; ensure containers are sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.