Description

1H-Azepine-4-Carboxaldehyde, Hexahydro-3-Hydroxy-2-Oxo- (9Ci) is a specialized heterocyclic building block with a unique fused ring structure containing aldehyde, ketone, and hydroxyl functional groups. This compound matters as a versatile chiral intermediate, enabling the synthesis of complex molecules with high stereochemical control for advanced research and development. It is primarily needed by pharmaceutical R&D chemists and fine chemical manufacturers working on novel active pharmaceutical ingredients (APIs), particularly in the areas of neurological and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and metabolic disease targets.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex, biologically active molecules with defined chirality.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals, agrochemicals, and advanced materials.
• Academic & Institutional Research: Used in universities and research institutes for methodological development in organic synthesis and catalysis.
• Process Chemistry Development: Investigated for scalable synthetic routes in pilot plants for potential commercial-scale API manufacturing.

Basic Information

Product Name	1H-Azepine-4-Carboxaldehyde, Hexahydro-3-Hydroxy-2-Oxo- (9Ci)
CAS No.	63447-34-7
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	Hexahydro-3-hydroxy-2-oxo-1H-azepine-4-carboxaldehyde; 4-Formyl-3-hydroxy-2-oxohexahydro-1H-azepine; 3-Hydroxy-2-oxohexahydro-1H-azepine-4-carbaldehyde; 1H-Azepine-4-carboxaldehyde, hexahydro-3-hydroxy-2-oxo-; (3R,4S)-3-Hydroxy-2-oxohexahydro-1H-azepine-4-carboxaldehyde (stereoisomer); 2-Oxo-3-hydroxyhexahydro-1H-azepine-4-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 1H-Azepine-4-Carboxaldehyde, Hexahydro-3-Hydroxy-2-Oxo- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storage under an inert gas such as argon or nitrogen in a freezer (-20°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (or as specified)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.