Description

trans-2-Cyano-1-Cyclohexanol is a versatile chiral building block and intermediate in organic synthesis. Its value lies in the presence of both a hydroxyl and a nitrile functional group on a cyclohexane ring, enabling its use in the production of complex molecules. This compound is primarily needed by the pharmaceutical, agrochemical, and fine chemical industries for research and development, as well as process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other specialty chemicals requiring a defined cyclohexanol structure.
• Ligand and Catalyst Development: Employed in the research and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Polymer Chemistry: Can be utilized as a monomer or modifier in the synthesis of specialty polymers with tailored properties.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	trans-2-Cyano-1-Cyclohexanol
CAS No.	63301-31-5
Molecular Formula	C7H11NO
Molecular Weight	125.17 g/mol
Synonyms	trans-2-Cyano-1-Cyclohexanol; (1R,2R)-2-Cyanocyclohexan-1-ol; (1S,2S)-2-Cyanocyclohexan-1-ol; 2-Cyanocyclohexanol; 1-Cyclohexanol, 2-cyano-, trans-; (±)-trans-2-Cyanocyclohexanol; Cyclohexanol, 2-cyano-, trans-; 2-Cyano-trans-1-cyclohexanol
EINECS	Contact for details

Quality Control

Our trans-2-Cyano-1-Cyclohexanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical assay, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.