Description

Cbz-D-Phenylalaninal CAS NO 63219-70-5 is a protected amino acid derivative, specifically the aldehyde form of D-phenylalanine with a carboxybenzyl (Cbz) protecting group on the amine. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, enabling the precise construction of biologically active molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce D-phenylalanine residues with orthogonal amine protection.
• Protease Inhibitor Research: Serves as a precursor in the development of inhibitors for proteolytic enzymes like renin and HIV protease.
• Chemical Biology Probes: Employed in the creation of labeled peptides and activity-based probes for studying protein function and interactions.
• Asymmetric Catalysis: Acts as a substrate or ligand precursor in catalytic reactions to induce chirality in target molecules.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	Cbz-D-Phenylalaninal
CAS No.	63219-70-5
Molecular Formula	C17H17NO3
Molecular Weight	283.32 g/mol
Synonyms	N-Carbobenzoxy-D-phenylalaninal; (R)-2-(((Benzyloxy)carbonyl)amino)-3-phenylpropanal; D-N-Cbz-Phenylalaninal; Nα-Cbz-D-Phenylalaninal; (R)-N-Carbobenzyloxy-phenylalaninal; Z-D-Phe-H; Benzyl (R)-(1-formyl-2-phenylethyl)carbamate
EINECS	Contact for details

Quality Control

Our Cbz-D-Phenylalaninal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents and moisture. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.