Description

2-(4-Pentynyloxy)Tetrahydro-2H-Pyran is a versatile protected alkyne building block, specifically a tetrahydropyran (THP)-protected 5-pentyn-1-ol. This compound is valued for its role in facilitating complex organic syntheses where the terminal alkyne functionality needs to be temporarily masked. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing molecular scaffolds, click chemistry applications, and polymer synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne handles for subsequent coupling reactions.
• Click Chemistry Reagent: Serves as a protected precursor for Huisgen cycloaddition (copper-catalyzed azide-alkyne cycloaddition) reactions, enabling efficient bioconjugation and material functionalization.
• Agrochemical Synthesis: Used in the development of novel crop protection agents and herbicides that require alkyne-based molecular architectures.
• Polymer & Material Science: Acts as a monomer or functionalization agent in the creation of specialty polymers, dendrimers, and functional surfaces.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes for natural product synthesis and the preparation of complex heterocycles.
• Ligand & Catalyst Development: Useful in the preparation of specialized ligands for catalysis and molecular recognition studies.

Basic Information

Item	Details
Product Name	2-(4-Pentynyloxy)Tetrahydro-2H-Pyran
CAS No.	62992-46-5
Molecular Formula	C10H16O2
Molecular Weight	168.23 g/mol
Synonyms	5-[(Tetrahydro-2H-pyran-2-yl)oxy]-1-pentyne; 1-Pentyne, 5-[(tetrahydro-2H-pyran-2-yl)oxy]-; THP-protected 5-pentyn-1-ol; 2-(4-Pentyn-1-yloxy)tetrahydropyran; 5-(Tetrahydro-2-pyranyloxy)-1-pentyne; 2-(Pent-4-yn-1-yloxy)tetrahydro-2H-pyran; 4-Pentyn-1-ol, tetrahydropyranyl ether
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Pentynyloxy)Tetrahydro-2H-Pyran is produced and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via GC, HPLC, and NMR is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.